diff --git a/components/input/OTP/OTPInput.tsx b/components/input/OTP/OTPInput.tsx
index 592c99fd0e..e7a5a4e249 100644
--- a/components/input/OTP/OTPInput.tsx
+++ b/components/input/OTP/OTPInput.tsx
@@ -37,11 +37,15 @@ const OTPInput = React.forwardRef<InputRef, OTPInputProps>((props, ref) => {
   };
 
   // ======================== Keyboard ========================
-  const onInternalKeyDown: React.KeyboardEventHandler<HTMLInputElement> = ({ key }) => {
+  const onInternalKeyDown: React.KeyboardEventHandler<HTMLInputElement> = (event) => {
+    const { key, ctrlKey, metaKey } = event;
+
     if (key === 'ArrowLeft') {
       onActiveChange(index - 1);
     } else if (key === 'ArrowRight') {
       onActiveChange(index + 1);
+    } else if (key === 'z' && (ctrlKey || metaKey)) {
+      event.preventDefault();
     }
 
     syncSelection();
diff --git a/components/input/__tests__/otp.test.tsx b/components/input/__tests__/otp.test.tsx
index 5d0707728d..877493166d 100644
--- a/components/input/__tests__/otp.test.tsx
+++ b/components/input/__tests__/otp.test.tsx
@@ -4,7 +4,7 @@ import Input from '..';
 import focusTest from '../../../tests/shared/focusTest';
 import mountTest from '../../../tests/shared/mountTest';
 import rtlTest from '../../../tests/shared/rtlTest';
-import { fireEvent, render, waitFakeTimer } from '../../../tests/utils';
+import { createEvent, fireEvent, render, waitFakeTimer } from '../../../tests/utils';
 
 const { OTP } = Input;
 
@@ -191,4 +191,13 @@ describe('Input.OTP', () => {
     fireEvent.input(inputs[3], { target: { value: '4' } });
     expect(onInput).toHaveBeenCalledWith(['1', '2', '3', '4']);
   });
+
+  it('disabled ctrl + z', () => {
+    const { container } = render(<OTP length={4} defaultValue="1234" />);
+    const inputEle = container.querySelector('input')!;
+    const event = createEvent.keyDown(inputEle, { key: 'z', ctrlKey: true });
+    fireEvent(inputEle, event);
+
+    expect(event.defaultPrevented).toBeTruthy();
+  });
 });