diff --git a/ports/matio/CMakeLists.txt b/ports/matio/CMakeLists.txt
deleted file mode 100644
index d7b6bb61be..0000000000
--- a/ports/matio/CMakeLists.txt
+++ /dev/null
@@ -1,60 +0,0 @@
-cmake_minimum_required(VERSION 3.8.0)
-project(libmatio C)
-
-set(SRC
-  src/endian.c
-  src/inflate.c
-  src/io.c
-  src/mat.c
-  src/mat4.c
-  src/mat5.c
-  src/mat73.c
-  visual_studio/matio.def
-  src/matvar_cell.c
-  src/matvar_struct.c
-  src/read_data.c
-  src/snprintf.c
-)
-
-add_library(libmatio ${SRC})
-target_include_directories(libmatio PRIVATE src visual_studio)
-target_compile_definitions(libmatio PRIVATE
-  -DH5_NO_DEPRECATED_SYMBOLS
-  -DMAT73=1
-  -DREPLACE_GETOPT
-  -DMATIO_HAVE_INTTYPES_H=1
-  -DMATIO_HAVE_STDINT_H=1
-)
-
-find_package(ZLIB REQUIRED)
-target_link_libraries(libmatio PRIVATE ZLIB::ZLIB)
-target_compile_definitions(libmatio PRIVATE -DHAVE_ZLIB=1)
-
-find_package(hdf5 CONFIG REQUIRED)
-
-if(BUILD_SHARED_LIBS)
-  target_compile_definitions(libmatio PRIVATE -DHAVE_HDF5=1 -DH5_BUILT_AS_DYNAMIC_LIB)
-  if(HDF5_USE_STATIC_LIBRARIES)
-    target_link_libraries(libmatio PRIVATE hdf5::hdf5-static hdf5::hdf5_hl-static)
-  else()
-    target_link_libraries(libmatio PRIVATE hdf5::hdf5-shared hdf5::hdf5_hl-shared)
-  endif()
-else()
-  target_compile_definitions(libmatio PRIVATE -DHAVE_HDF5=1 -DH5_BUILT_AS_STATIC_LIB)
-  target_link_libraries(libmatio PRIVATE hdf5::hdf5-static hdf5::hdf5_hl-static)
-endif()
-
-install(
-  TARGETS libmatio
-  RUNTIME DESTINATION bin
-  LIBRARY DESTINATION lib
-  ARCHIVE DESTINATION lib
-)
-
-if(NOT DISABLE_INSTALL_HEADERS)
-  install(FILES
-    src/matio.h
-    visual_studio/matio_pubconf.h
-    DESTINATION include
-  )
-endif()
diff --git a/ports/matio/CONTROL b/ports/matio/CONTROL
deleted file mode 100644
index 0d304a646d..0000000000
--- a/ports/matio/CONTROL
+++ /dev/null
@@ -1,5 +0,0 @@
-Source: matio
-Version: 1.5.19
-Homepage: https://github.com/tbeu/matio
-Description: MATLAB MAT File I/O Library
-Build-Depends: zlib, hdf5
diff --git a/ports/matio/fix-dependencies.patch b/ports/matio/fix-dependencies.patch
new file mode 100644
index 0000000000..03304d0832
--- /dev/null
+++ b/ports/matio/fix-dependencies.patch
@@ -0,0 +1,28 @@
+diff --git a/cmake/thirdParties.cmake b/cmake/thirdParties.cmake
+index 41d8529..392d455 100644
+--- a/cmake/thirdParties.cmake
++++ b/cmake/thirdParties.cmake
+@@ -19,7 +19,7 @@ if(MATIO_WITH_HDF5)
+         endif()
+         set(HDF5_FOUND TRUE)
+     else()
+-        find_package(HDF5)
++        find_package(HDF5 CONFIG REQUIRED)
+         if(HDF5_FOUND)
+             set(HDF_MIN_VER 1.8)
+             if(HDF5_VERSION VERSION_LESS ${HDF_MIN_VER})
+@@ -44,9 +44,12 @@ if(HDF5_FOUND)
+     elseif(TARGET hdf5)
+         # target from hdf5 1.8 config
+         target_link_libraries(MATIO::HDF5 INTERFACE hdf5)
+-    elseif(TARGET HDF5::HDF5)
++    elseif(TARGET hdf5::hdf5-shared)
+         # target defined in CMake FindHDF5 (since 3.19)
+-        target_link_libraries(MATIO::HDF5 INTERFACE HDF5::HDF5)
++        target_link_libraries(MATIO::HDF5 INTERFACE hdf5::hdf5-shared)
++    elseif(TARGET hdf5::hdf5-static)
++        # target defined in CMake FindHDF5 (since 3.19)
++        target_link_libraries(MATIO::HDF5 INTERFACE hdf5-static)
+     else()
+         # results from CMake FindHDF5
+         set_target_properties(MATIO::HDF5 PROPERTIES
diff --git a/ports/matio/portfile.cmake b/ports/matio/portfile.cmake
index a1e55d41dd..c72bd3e4d0 100644
--- a/ports/matio/portfile.cmake
+++ b/ports/matio/portfile.cmake
@@ -4,18 +4,34 @@ vcpkg_from_github(
     REF ca56394e5672115df1981996ed12524d1d551259 # v1.5.19
     SHA512 67c239d8aabafaa935775f3b260ba0756c196b0d845ef5116365c9aa6a0b24dae70d92c4e74d5d43ae073ae0744f084f0f58ead864eb77c813d43dbbb3e4ec5e
     HEAD_REF master
+    PATCHES fix-dependencies.patch
 )
 
-file(COPY ${CMAKE_CURRENT_LIST_DIR}/CMakeLists.txt DESTINATION ${SOURCE_PATH})
+string(COMPARE EQUAL "${VCPKG_LIBRARY_LINKAGE}" "dynamic" BUILD_SHARED)
 
-vcpkg_configure_cmake(
+vcpkg_check_features(OUT_FEATURE_OPTIONS FEATURE_OPTIONS
+    FEATURES
+        hdf5            MATIO_WITH_HDF5
+        zlib            MATIO_WITH_ZLIB
+        extended-sparse MATIO_EXTENDED_SPARSE
+        mat73           MATIO_MAT73
+        pic             MATIO_PIC
+)
+
+vcpkg_cmake_configure(
     SOURCE_PATH ${SOURCE_PATH}
     PREFER_NINJA
-    OPTIONS_DEBUG -DDISABLE_INSTALL_HEADERS=ON
+    OPTIONS ${FEATURE_OPTIONS}
+        -DMATIO_SHARED=${BUILD_SHARED}
+        -DMATIO_USE_CONAN=OFF
 )
 
-vcpkg_install_cmake()
-
-file(INSTALL ${SOURCE_PATH}/COPYING DESTINATION ${CURRENT_PACKAGES_DIR}/share/matio RENAME copyright)
+vcpkg_cmake_install()
 
 vcpkg_copy_pdbs()
+
+vcpkg_copy_tools(TOOL_NAMES matdump AUTO_CLEAN)
+
+file(REMOVE_RECURSE "${CURRENT_PACKAGES_DIR}/debug/include")
+
+file(INSTALL "${SOURCE_PATH}/COPYING" DESTINATION "${CURRENT_PACKAGES_DIR}/share/${PORT}" RENAME copyright)
diff --git a/ports/matio/vcpkg.json b/ports/matio/vcpkg.json
new file mode 100644
index 0000000000..7e4b8d05ad
--- /dev/null
+++ b/ports/matio/vcpkg.json
@@ -0,0 +1,40 @@
+{
+  "name": "matio",
+  "version-semver": "1.5.19",
+  "port-version": 1,
+  "description": "MATLAB MAT File I/O Library",
+  "homepage": "https://github.com/tbeu/matio",
+  "dependencies": [
+    {
+      "name": "vcpkg-cmake",
+      "host": true
+    }
+  ],
+  "default-features": [
+    "hdf5",
+    "zlib"
+  ],
+  "features": {
+    "extended-sparse": {
+      "description": "Enable extended sparse matrix data types not supported in MATLAB"
+    },
+    "hdf5": {
+      "description": "Check for HDF5 library",
+      "dependencies": [
+        "hdf5"
+      ]
+    },
+    "mat73": {
+      "description": "Enable support for version 7.3 MAT files"
+    },
+    "pic": {
+      "description": "Enable position-independent code (PIC), i.e., compilation with the -fPIC flag"
+    },
+    "zlib": {
+      "description": "Check for zlib library",
+      "dependencies": [
+        "zlib"
+      ]
+    }
+  }
+}
diff --git a/versions/baseline.json b/versions/baseline.json
index 655d131b35..8204db2073 100644
--- a/versions/baseline.json
+++ b/versions/baseline.json
@@ -3910,7 +3910,7 @@
     },
     "matio": {
       "baseline": "1.5.19",
-      "port-version": 0
+      "port-version": 1
     },
     "matplotlib-cpp": {
       "baseline": "2020-08-27",
diff --git a/versions/m-/matio.json b/versions/m-/matio.json
index 12b26f4ece..74bf34be5d 100644
--- a/versions/m-/matio.json
+++ b/versions/m-/matio.json
@@ -1,5 +1,10 @@
 {
   "versions": [
+    {
+      "git-tree": "c11c8ba1ca5c7f0286165d497088779ec0df756a",
+      "version-semver": "1.5.19",
+      "port-version": 1
+    },
     {
       "git-tree": "09b997c5cb31fdde33faf650612324a847967360",
       "version-string": "1.5.19",