diff --git a/ports/itk/portfile.cmake b/ports/itk/portfile.cmake
index 65057293f1..459e1af0ec 100644
--- a/ports/itk/portfile.cmake
+++ b/ports/itk/portfile.cmake
@@ -204,4 +204,12 @@ file(REMOVE "${CURRENT_PACKAGES_DIR}/include/ITK-5.3/vcl_where_root_dir.h")
 vcpkg_replace_string("${CURRENT_PACKAGES_DIR}/include/ITK-5.3/itk_eigen.h" "include(${SOURCE_PATH}/CMake/UseITK.cmake)" "include(UseITK)")
 vcpkg_replace_string("${CURRENT_PACKAGES_DIR}/include/ITK-5.3/itk_eigen.h" "message(STATUS \"From ITK: Eigen3_DIR: ${CURRENT_INSTALLED_DIR}/share/eigen3\")" "")
 
+if("rtk" IN_LIST FEATURES)
+    vcpkg_replace_string("${CURRENT_PACKAGES_DIR}/include/ITK-5.3/rtkConfiguration.h" "#define RTK_BINARY_DIR \"${CURRENT_BUILDTREES_DIR}/${TARGET_TRIPLET}-rel/Modules/Remote/RTK\"" "")
+    vcpkg_replace_string("${CURRENT_PACKAGES_DIR}/include/ITK-5.3/rtkConfiguration.h" "#define RTK_DATA_ROOT \"${CURRENT_BUILDTREES_DIR}/${TARGET_TRIPLET}-rel/ExternalData/Modules/Remote/RTK/test\"" "")
+
+    vcpkg_replace_string("${CURRENT_PACKAGES_DIR}/share/itk/Modules/RTK.cmake" "${CURRENT_BUILDTREES_DIR}/${TARGET_TRIPLET}-rel" "\${ITK_INSTALL_PREFIX}")
+    vcpkg_replace_string("${CURRENT_PACKAGES_DIR}/share/itk/Modules/RTK.cmake" "${SOURCE_PATH}/Modules/Remote/RTK/utilities/lp_solve" "\${ITK_INSTALL_PREFIX}/include/RTK/lpsolve")
+endif()
+
 file(INSTALL "${SOURCE_PATH}/LICENSE" DESTINATION "${CURRENT_PACKAGES_DIR}/share/${PORT}" RENAME copyright)
diff --git a/ports/itk/vcpkg.json b/ports/itk/vcpkg.json
index d6fdd6a90d..14cc6f912d 100644
--- a/ports/itk/vcpkg.json
+++ b/ports/itk/vcpkg.json
@@ -1,7 +1,7 @@
 {
   "name": "itk",
   "version": "5.2.1",
-  "port-version": 3,
+  "port-version": 4,
   "description": "Insight Segmentation and Registration Toolkit (ITK) is used for image processing and analysis.",
   "homepage": "https://github.com/InsightSoftwareConsortium/ITK",
   "license": "Apache-2.0",
diff --git a/versions/baseline.json b/versions/baseline.json
index 186f4c1c02..52f8ae3106 100644
--- a/versions/baseline.json
+++ b/versions/baseline.json
@@ -3194,7 +3194,7 @@
     },
     "itk": {
       "baseline": "5.2.1",
-      "port-version": 3
+      "port-version": 4
     },
     "itpp": {
       "baseline": "4.3.1",
diff --git a/versions/i-/itk.json b/versions/i-/itk.json
index ecc09cae81..8526fd87bb 100644
--- a/versions/i-/itk.json
+++ b/versions/i-/itk.json
@@ -1,5 +1,10 @@
 {
   "versions": [
+    {
+      "git-tree": "b28c11dddebdeb5084e068f2ad88e87b777f5edb",
+      "version": "5.2.1",
+      "port-version": 4
+    },
     {
       "git-tree": "a3904d4a80201635e6687ff2b5ca5d677b559874",
       "version": "5.2.1",